Maps, Directions, and Place Reviews
No longer T-cell?
What's the authority for saying that "so-called" T-cell CLLs are a separate disease group (and not a subset of CLL)? Who recognizes it?
eMedicine still considers T-cell CLL as CLL as of October 2008. eMedicine Chronic Lymphocytic Leukemia Approximately 2-5% of patients with chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL) exhibit a T-cell phenotype.
Is this a consensus or is this still under debate? Is it something that the broad oncology community agrees on, or is there a different perspective among sub-specialties or disciplines? How do you reconcile this with the eMedicine authors? Nbauman (talk) 18:43, 3 February 2009 (UTC)
Causes?
I just noticed that this article doesn't address the causes of CLL. It seems a little odd. Anyone have a favorite source? WhatamIdoing (talk) 03:11, 26 June 2009 (UTC)
HSCT
doi:10.1182/blood-2009-05-206821 Blood - review of indications for allogeneic stem cell transplantation. JFW | T@lk 19:39, 24 September 2009 (UTC)
Cell size
Does anyone know offhand whether this change is correct? It 'feels right' to me, but my brief search didn't produce a source that addresses this issue, and I don't know. WhatamIdoing (talk) 17:50, 28 September 2009 (UTC)
Research and Clinical trials
Could we have a section in/near Treatment mentioning any treatments undergoing late stage clinical trials that may be recruiting patients or nearing marketing approval ? Rod57 (talk) 00:25, 25 March 2010 (UTC)
Science News resource, News in Brief: Body & Brain
Gene therapy for leukemia Web edition: Thursday, August 18th, 2011 "Tweaking immune cells to attack cancer cells in leukemia patients can bring about remission, a small study shows. Scientists at the University of Pennsylvania genetically altered immune T cells to target malignant cells in chronic lymphocytic leukemia patients and mass produced the T cells before injecting them into three patients. The modified cells gravitated to bone marrow, where they killed malignant cells. In two of three patients tested the cancer went into remission, and a portion of the genetically modified T cells persisted, possibly as a cadre of defenders on standby. The researchers report the findings in the Aug. 10 Science Translational Medicine." by Nathan Seppa
99.181.140.213 (talk) 04:33, 26 November 2011 (UTC)
Gene Mutations
The IGHV mutation status section is imho mistitled with "Gene Mutations". I would expect genetic aberrations to follow under that heading. However, the mutational status of the IGHV genes is a normal process to develop the B-cell immunglobulin genes and also occurs in non-malignant B-cells. In CLL, IGHV mutational status is only used to stratify patients into prognostic subgroups. Therefore, a better title would be "Patient Stratification according to Genetic Markers" or something similar. Gene mutations would e.g. be mutations of the TP53 gene or the ATM gene that both in CLL lead to resistance against chemotherapy and could be adressed under the "Gene Mutations" heading. -- Preceding unsigned comment added by Aimee Anouk (talk o contribs) 15:11, 16 May 2013 (UTC)
Chronic Lymphoid Leukaemia? Really?
Could the medics here confirm that CLL is commonly called "Chronic Lymphoid Leukaemia" as is stated in the lede, and only in the lede? I have only seen this term used here, and never come across it anywhere else. I'd like to remove it altogether, but there are editors here who I would defer to. Thanks -Roxy the dog (resonate) 23:10, 24 March 2014 (UTC)
Reviews
Blood has a series of reviews on CLL here. JFW | T@lk 09:03, 29 July 2015 (UTC)
IGHV mutations/FISH systematic review
doi:10.1182/blood-2015-10-620864 JFW | T@lk 08:05, 8 April 2016 (UTC)
Review
doi:10.1111/bjh.14184 JFW | T@lk 13:07, 20 June 2016 (UTC)
External links modified
Hello fellow Wikipedians,
I have just modified one external link on B-cell chronic lymphocytic leukemia. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
- Added archive https://web.archive.org/web/20110707080329/http://www.accessmedicine.com/content.aspx?aid=2149838 to http://www.accessmedicine.com/content.aspx?aid=2149838
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at {{Sourcecheck}}).
You may set the |checked=, on this template, to true or failed to let other editors know you reviewed the change. If you find any errors, please use the tools below to fix them or call an editor by setting |needhelp= to your help request.
- If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
- If you found an error with any archives or the URLs themselves, you can fix them with this tool.
If you are unable to use these tools, you may set |needhelp=<your help request> on this template to request help from an experienced user. Please include details about your problem, to help other editors.
Cheers.--InternetArchiveBot (Report bug) 05:05, 23 October 2016 (UTC)
Source of the article : Wikipedia
EmoticonEmoticon